Any GOCOVRI success stories?

The last two visits to my movement disorder specialist (MDS) each had a new doctor. Each doctor stopped previous med and started another.  Meds not optimized. Major off times.  

8/12/2024 — The latest doctor thinks a new medication GOCOVRI will help with the off times and dyskinesia. I'm concerned of constipation being a side effect. I’ve already been to the ER with constipation once before and it was no fun.  

8/13/2024 — Feeling pretty good so far after first night of gocovri. Giving it a week before doctor said to double dosage. Overall feeling somewhat better. Still getting two major off times with freezing around 10:30am and 5pm and other minor off times which last 15-30 minutes.

I’m thinking it is related to food in my gut conflicting with the absorption of levodopa. Hard to work around this when I take C/L every two hours.  Not giving up hope, I think back to last time I saw the original doctor I saw at this neurology office who reassured me there are many things to try and new treatments awaiting FDA approval.

8/21/2024 I started to take two GOCOVRI pills a night last night. So far I have a headache, but nothing else.

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Gut Microbiome Changes May Be an Early Sign of PD

New Study Finds That Gut Microbiome Changes May Be an Early Sign of Parkinson's Disease Long Before Traditional Symptoms Appear

The researchers hope these initial findings can help lead to earlier diagnosis (and treatment) of the neurodegenerative disease.

A new study published May 2, 2023 in the journal Nature Communications reveals another possible way we might be able to spot Parkinson's disease early—and even before noticeable symptoms arise.

According to this research, there are noticeable changes in the gut microbiota during the earliest stages of Parkinson's disease, and this may help doctors diagnose and offer targeted treatment before the disease progresses further.

Read article on eatingwell

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